A PARADIGM SHIFT IN THE MANAGEMENT OF CHRONIC INFECTION.Understanding biofilm and the clinical challenge of the EPS of a biofilm
THE PROBLEM OF BIOFILM
Nearly 80% of all global bacterial infections are associated with biofilm bacteria. 1
In contrast to planktonic bacteria, biofilm is a complex, organised bacterial community possessing a sophisticated protective armour, in the form of the extracellular polymeric substance (EPS) which prevents the bacteria from being exposed.
THE CLINICAL CHALLENGE
Chronic infections affect 17 million people annually in the US, and approximately 550,000 people die as a result of their chronic infections. 2
The challenge with biofilm related infections is that they cannot be adequately confirmed via diagnostic tests in the clinical setting, and more importantly, they are intrinsically resistant to host immunity, antibiotics, and biocides. This renders current therapeutic options inadequate to successfully eradicate the infection.
Next Science has applied novel material science methods to combat biofilm.
The proprietary targeted technology offers a unique and unprecedented approach to overcoming biofilm bacteria by creating an environment that compromises the integrity of the biofilm. In doing so, the break down and removal of the EPS is enabled, facilitating targeting of the pathogens within the environment and preventing reformation of the biofilm.
A material science method involves exploring how the structure of something influences its physical and chemical properties and performance, in this case with a view to understand how a treatment can deconstruct and destroy it.
Most traditional therapeutic options ignore the physical and chemical structure, instead taking a biochemical approach that alters the chemical processes of an organism to eliminate it.
In the case of eradicating biofilm, the biochemical approach has proven less effective than applying a material science approach.